Biology and Biochemistry Methods Search EngineDoing a PhD is about the pursuit of knowledge

The typical biology PhD student spends 5+ years in a PhD program. If you were to follow a student, you might start in the morning by watching him/her looking through papers to check what latest research might be out there related to their topic. Have they been scooped? Is there contradictory research out there that they now have to mention in their next research paper? What new information can they glean from their PubMed searches to understand their research challenges better and inch their way forward with their existing hypothesis?

Note: If you’re writing research papers, I highly recommend Grammarly – it’s a free grammar check plugin for Chrome. Try it out here

After performing broad searches on their field of specialization, they would then narrow down their focus on their task at hand. How do I get to my next publication? How can I prove that my protein is being expressed? Is it being degraded by proteases? What kind of data will I need to prove my hypothesis? Really, completing a PhD is all about answering questions and pursuing knowledge — ie performing Biology and Biochemistry ReSearch.  But, the tools that are typically used in this search are not efficient or complete. Academic research, even though it is considered at the edge of knowledge and understanding, moves at a snail’s pace because it lacks the right tools.


Improving research efficiency in Biology by using free tools like SciGine

This was the reason that SciGine was created. By using the SciGine search engine, I was hoping that future generations of Biologists and Biochemists would be able to more efficiently tackle their research. The website is set up such that any one can use it by going to SciGine and typing in the search box. The next page shows up results similar to how PubMed and Google organize results as individual biology methods with their search query highlighted along with the author name and time/year of publication. Clicking on an individual method then takes the user to a split screen view consisting of the method steps on the left and a notes section on the right.

I realized that many times, the methods we use for research are amalgamations from multiple articles. So why not design a user interface that allows visitors to take notes while viewing multiple methods easily? On a typical method such as Western Blotting for Kidney Amino-Acid Oxidase this makes method development very simple. I can search for multiple western blot methods using the Browse or Search functionality and then take notes on what exactly I want to do with a protein of interest to me on he right side of the screen. With over 1000+ results from a simple “Western Blot” search, I’m amazed at how much this would have helped me during my PhD.

Saving Biology Methods online for ease-of-access later in lab

Beyond simply taking notes, users can save their methods and protocols and keep a running list of them as part of their Online Methods Notebook. This page is for editing their user profile but also can be used as an online lab notebook. I can envision users using it to keep their day-to-day methods and results online or just to keep a general repository of the methods that they tried out. It’s especially useful to keep this information online because a user can, for example, share their immunoblot method with a lab mate easily and also view their method in lab via a phone or tablet while performing their experiment. There are also option to keep methods private (un-searchable) or public (searchable by everyone) so that important information doesn’t get into the wrong hands.

The ability to upload complete methods online also has the advantage of making it easy to write publications later on. Too often, in a publication, details of their methods are lacking.  By keeping track of what materials were used (especially their part numbers and vendors), the references that were combined to make a method, and how each material was used step-by-step, writing a “Materials and Methods” section for a publication will be a breeze. I want researchers to be able to determine if a chemical from Sigma Aldrich vs. Fisher Scientific was the culprit when it came to their bad data. SciGine will, I expect, improve the quality of research produced by it’s users.

Eventually, I expect there to be more viewers asking and answering questions specific to the methods that they find on SciGine. However, several other resources exist which can help with questions for now. In particular Research Gate and Protocols Online have active communities on their forums that make it easy to get questions answered.

Thank you for reading about the inception of SciGine and how it can be used to advance your Biology and Biochemistry research. Look forward to more posts in the future!



Note: Grammarly is a free grammar check plugin for Chrome. I used it for this article and really like it! Try it out here

By Karthik Raman, PhD

I am a PhD Bioengineer specialized in utilizing heparan sulfate and heparin for drug delivery to brain tumors. My expertise lies in the interface between polymer chemistry, protein biochemistry, and cellular biology.

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